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KMID : 1039120150040010114
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Clinical and Experimental Vaccine Research
2015 Volume.4 No. 1 p.114 ~ p.118
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Antigenic properties and virulence of foot-and-mouth disease virus rescued from full-length cDNA clone of serotype O, typical vaccine strain
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Kim Rae-Hyung
Chu Jia-Qi
Park Jeong-Nam
Lee Seo-Yong
Lee Yeo-Joo
Ko Mi-Kyeong
Hwang Ji-Hyeon
Lee Kwang-Nyeong
Kim Su-Mi
Tark Dong-Seob
Ko Young-Joon
Lee Hyang-Sim
Seo Min-Goo
Park Min-Eun
Kim Byoung-Han
Park Jong-Hyeon
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Abstract
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We cloned the full-length cDNA of O Manisa, the virus for vaccinating against foot-and-mouth disease. The antigenic properties of the virus recovered from the cDNA were similar to those of the parental virus. Pathogenesis did not appear in the pigs, dairy goats or suckling mice, but neutralizing antibodies were raised 5-6 days after the virus challenge. The utilization of O Manisa as a safe vaccine strain will increase if recombinant viruses can be manipulated by inserting or removing a marker gene for differential serology or replacing the protective gene from another serotype.
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KEYWORD
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Foot-and-mouth disease, Vaccine, Molecular cloning
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